Rob Paulsen

Pinky (voice)

Maurice LaMarche

The Brain (voice)

Tress MacNeille

Brie (voice) / Bernie (voice) / Princess Dot (voice) / Janet (voice) / Dave Burl (voice) / Marna Strutt (voice) / Rue McClanahy (voice) / Female Rock Star (voice) / Eisenhower (voice) / Mousealope Calf (voice) / Katie C. (voice) / Queen Roach / First Lady / Time Machine Computer (voice) / Mrs. Applebee (voice) / Old Woman (voice) / First Lady (voice) / Sully (voice) / Japanese Girl (voice) / Billie (voice) / Greta (voice) / Phyllis (voice) / Cheerleader (voice) / Mary Hartless (voice) / Passerby (voice) / Wench (voice) / Rikki Lake (voice)

Frank Welker

Grandfather (voice) / Girth Plotz (voice) / Fred flopped (voice) / Bartender (voice) / Gollyzilla (voice) / Mr. President (voice) / Ross Perot (voice) / Maurice (voice) / The President (voice) / General Odin (voice) / Fred Floppel (voice)

Jeff Bennett

Kale Mumphausen (voice) / Leonard Sheldon (voice) / Zalgar (voice) / Alan Fontain Bisque (voice) / Tom Cajones (voice) / Dr. Mordough (voice) / Christopher W. (voice) / Sampson (voice) / Game Announcer (voice) / Baloney (voice) / Chris (voice) / Wensleydale (voice) / Locke (voice) / Schotzie (voice) / Hippie (voice) / Kilmer (voice)

Roddy McDowall

Snowball (voice)

Corey Burton

Strawboater (voice) / Evil Clown (voice) / Cushing (voice)

Billy West

Larry (voice) / Receptionist (voice) / Dean (voice) / Earl Wendell (voice) / Anthony H. (voice)

Jim Cummings

The Mist (voice) / Fred Floppel (voice) / V/O #1 (voice) / Chuck (voice) / Punk (voice)

Jess Harnell

Alien Singer (voice) / Wakk Skylicker (voice) / Fred Spinatra (voice)

Laraine Newman

Secretary (voice)

Julie Brown

Danette Spoonabello (voice) / Minerva Mink (voice)