Paul Rugg

Freakazoid (voice)

Ed Asner

Sgt. Cosgrove (voice)

Joe Leahy

Our Narrator (voice) / Our Announcer (voice)

Tress MacNeille

Debbie Douglas (voice) / Debbie Douglas / Dot Warner / Valerie (voice) / Speaker (voice) / Debbie Douglas / Sharon Stone / Additional Voices (voice) / Helen (voice) / Girl / Assistant (voice) / Cobra Queen (voice) / Anchorwoman (voice) / Mary Beth (voice) / Cobra Queen / Debbie Douglas / Additional Voices (voice) / Debbie Douglas / Dot Warner / Additional Voices (voice) / Secretary (voice) / Christina / Additional Voices (voice) / Debbie Douglas / Intern Singer (voice) / Babeheart (voice) / Cobra Queen / Additional Voices (voice) / Princess Di / Sharon Stone / Hillary Clinton / Additional Voices (voice)

Jeff Bennett

Cave Guy / Singer #2 (voice) / AI / Additional Voices (voice) / Mike / Captain Harrison (voice) / Cave Guy (voice) / The Huntsman / Singer (voice) / Cave Guy / Mike / The Huntsman / Additional Voices (voice) / Mike / Storch Club Singer (voice) / Lord Bravery (voice) / Cave Guy / Waylon Jeepers (voice) / Manager (voice) / The Huntsman (voice) / Attendant (voice) / Medulla / Bathroom Patron (voice) / Bearded Archeologist / The Huntsman / Lord Bravery (voice) / Jeepers / Dracula (voice) / Candle Jack / Dr. Sins / Additional Voices (voice) / Keir Dullea (voice) / Cave Guy / Waylon Jeepers / Candle Jack / Additional Voices (voice) / The Huntsman / Cave Guy / Kid Carrion / Additional Voices (voice)

Frank Welker

The President / Additional Voices (voices) / Mr. Chubbikins (voice) / Big Snake (voice) / The Judge (voice) / Pterodactyl (voice) / Steven Spielberg / E.T. / Additional Voices (voice) / Santa / Additional Voices (voice) / Gulliver / Storch Club Waiter (voice) / Gen. Toku (voice) / Mr. Chubbikins / Additional Voices (voice) / Fred the Guard / Additional Voices (voice) / Foamy The Freakadog (voice) / Crow (voice) / The President / Additional Voices (voice)

John P. McCann

Douglas Douglas / Additional Voices (voice) / Hero Boy (voice) / Douglas Douglas / Baseball Announcer (voice) / Douglas Douglas (voice) / Douglas Douglas / Jubel Lee / Self (voice)

Maurice LaMarche

Eric the Large / Rathgar (voice) / The Brain / Additional Voices (voice) / Captain Kirk / Bill Gates / Additional Voices (voice) / The Brain (voice) / Longhorn / Medulla / Lord Pringle / Additional Voices (voice) / Longhorn / Presenter (voice) / Longhorn (voice) / Krimson Kvetch (voice) / Dan (voice)

David Kaufman

Dexter Douglas (voice)

Tracy Rowe

Steff (voice)

David Warner

The Lobe (voice)

Rob Paulsen

George Takei (voice) / Self / Lord Bravery Singers (voice) / Yakko Warner / Freddy Bob (voice) / Pinky / Japanese Pilot (voice) / Lord Bravery Singers / Dog Catcher (voice) / Yakko Warner (voice) / Mohammed-Abdul (voice) / Francois / Cosmo Kramer (voice)