Will Forte

Abe Lincoln / Narrator (voice)

Phil Lord

Principal Dr. Cinnamon J. Scudworth (voice)

Michael McDonald

Gandhi (voice)

Christa Miller

Cleopatra (voice)

Christopher Miller

JFK / Mr. Butlertron (voice)

Nicole Sullivan

Joan of Arc (voice)

Neil Flynn

E-CyboPooch / Pirate / Rich Man / Moses (voice) / Snowflake Jake / Julius Caesar / Carl (voice / Gandhi's Foster Father / Zoo Worker (voice) / Julius Caesar / Carl (voice) / Carl (voice) / Buddy Holly (voice) / Julius Caesar (voice) / Glen the Janitor / Julius Caesar (voice) / Julius Caesar / Tux Guy / Moses (voice)

Donald Faison

Toots / Wally (voice) / Jimi Hendrix / Wally (voice) / Toots / King Kwanzaa / Wally / Guy in Commercial (voice) / George Washington Carver (voice) / Inmate (voice) / George Washington Carver / Wally (voice) / X-Stream Bob / Wally (voice) / Martin Luther King Jr. / Toots (voice) / Toots (voice)

Andy Dick

Police Officer (voice) / Mr. Sheepman / Van Gogh / Police Officer (voice) / Mr. Sheepman / Thomas Edison / Van Gogh / Police Officer (voice) / Mr. Sheepman (voice) / Van Gogh (voice) / Mr. Sheepman / Thomas Edison / Sexual Education Officer (voice)

Bill Lawrence

The Shadowy Figure (voice) (uncredited)

Judah Miller

Scangrade (voice) / Dreidelstein (voice) / Inmate (voice)

Murray Miller

Gene Kelly (voice) (uncredited) / Catherine the Great (voice)