Rob Paulsen

Yakko Warner / Pinky (voice)

Jess Harnell

Wakko Warner (voice)

Tress MacNeille

Dot Warner (voice)

Maurice LaMarche

Brain (voice)

Frank Welker

Cat (voice) / Baby Boo (voice) / Ralph / Clunko (voice) / Ralphicus (voice) / Ralph / Vampire (voice) / Chicken Boo (voice) / Ralph / Waiter (voice) / Horse (voice) / Jackass Monkey / Ralph (voice) / Ralph Yakko (voice) / Ralph (voice) / King (voice) / Male Gallery Member / Ralphus (voice) / Priest (voice) / Constable Ralphers / Judge Plotz (voice) / 23 & WB Employee / Ralph (voice) / Teamster #1 (voice)

Danny Jacobs

Starbox (voice) / Hysterical Conductor (voice) / Baldo / Driver / Villager (voice) / Male Reporter 1 / Princeton Russell (voice) / Lawyer (voice) / Dwayne LaPistol (voice) / Russian Tech (voice) / Dust-Boy / Scientist / Security Guard (voice) / Crier (voice) / Van Gogh (voice) / Chief Thief (voice) / Grubb (voice)

Kari Wahlgren

Stapler / Teenage Butterfly (voice) / Teen Employee (voice) / Phonenicia (voice) / Marsha (voice) / Audience Member / Narrator / Kid #1 (voice) / Kelly Sue / Mom (voice) / Athena / Tourist (voice) / Marla (voice) / Kid / Woman (voice) / Symphony B (voice) / Brilly Brumley / Sheila Lickspittle (voice) / May the Mayfly (voice) / Glowing Eyes (voice) / Teenager #2 (voice)

Fred Tatasciore

Founding Father (voice) / Announcer / Beastwipe (voice) / Nils (voice) / Lobbyist (voice) / Nero / Nils (voice) / Ivan the Terrible / The Rat-sputin / Yakov (voice) / Demon Judge / Nils / Old Man (voice) / Benedict (voice) / Contestant #1 / Contestant #2 / Mr. Relatable (voice)

Jake Green

Glowing Eyes (voice) / Noah (voice) / Pageant Registrar (voice) / Bieber Monster / Shipmate (voice) / Male Guard / Snowden (voice) / BoysStorm Boys / Teenager #3 (voice) / Meatball Man (voice) / Fred Bagel / P.A. (voice) / Correction Fluid (voice) / Dorko / Dweebo (voice) / Bradimir / Contestant / Military Police 2 (voice)

Carlos Alazraqui

Conductor / Moose (voice) / Announcer (voice) / Lotto Announcer (voice) / Ed / Grandson (voice) / Nicolás Maduro / Rodrigo (voice) / Joe (voice) / John (voice) / Mexican Commentator / Venezuelan Host (voice) / Tuck Buckerson (voice) / Leader Alien (voice)

Stephanie Escajeda

Nora Rita Norita / Email #3 (voice) / Woman (voice) / Nora Brownlow (voice) / Nora Rita Norita (voice)

Rachael MacFarlane

Boss (voice) / Nancy / Urchin (voice) / Lady in Bank (voice) / Alien (voice) / Jean Gravy (voice) / Gillian / Left Mother (voice) / Announcer / Dandelion (voice) / Daycare Worker 2 / Mother / Toddler 2 (voice) / Elizabeth / Dot's Assistant (voice)